Dr. Frederick Zeiler
Background: Dr. Frederick Zeiler is a Canadian neurosurgeon who joined the University of Manitoba as a clinician-scientist in 2019 and is currently a Full Professor and the Endowed MPI Chair in Neuroscience. He earned his BSc from the University of Manitoba, focusing on applied mathematics and physical chemistry. During this time, he received Natural Sciences and Engineering Research Council of Canada (NSERC) summer research awards. He completed his medical school and neurosurgery residency at the University of Manitoba. Furthering his expertise, Dr. Zeiler pursued fellowship training in neurocritical care at the Montreal Neurological Institute and in the clinician investigator program at the University of Manitoba. Finally, he pursued his PhD at the University of Cambridge, focusing on advanced multi-modal cerebral physiologic monitoring, biosignal analytics, and machine learning approaches in acute biomechanical traumatic neural injury. He worked under the supervision of Professors David Menon and Marek Czosnyka, renowned experts in acute neural injury research. During his time at Cambridge, Zeiler was recognized as the RCPSC Morton Traveling Fellow in Surgery and a University of Cambridge International Trust Scholar. He is subsequently dual-certified in neurosurgery and as a clinician-investigator by the Royal College of Physicians and Surgeons of Canada (RCPSC).
Research Interests: Dr. Zeiler leads the Multi-omic Analytics and Integrative Neuroinformatics in the HUman Brain (MAIN-HUB) Lab at UM. Independently funded, the lab focuses on bridging knowledge gaps in cerebral physiological relationships in humans and large mammals. It advances natural science and engineering fields using innovative biosignal analytics, mathematical modeling, and network analytic approaches to high-frequency multi-modal data streams. The lab aims to improve understanding of cerebral pressure-flow and nutrient delivery dynamics in multi-variate space, in both healthy states and under biomechanical strain. It generates high-resolution physiological trajectory state-space models and develops new metrics and devices for continuous evaluation of cerebral physiological processes in real-time, benefiting humans and large mammals. The overarching goal is to enhance whole-brain capacity to characterize continuous cerebral physiology, predict physiological events, and understand fundamental physiological relations. Long-term objectives include uncovering mechanisms of impaired cerebrovascular function in various health and disease states, particularly biomechanical neural injury, to identify potential therapeutic targets.
The lab operates at the intersection of biomedical engineering, complex statistical methodologies, data science techniques, biosignal processing and analytics, novel metric/device development, and multi-variate state-space trajectory modeling. Maintaining strong collaborative ties with international centers such as the University of Cambridge, Karolinska Institute, University of Helsinki, and Maastricht University, the lab engages in multi-center research initiatives focusing on big data approaches in multi-dimensional multi-omics to deepen understanding of cerebral physiological responses in health and disease.
Recognition: Currently, Dr. Zeiler holds the position of Full Professor within the Section of Neurosurgery (Dept of Surgery), and Graduate Program in Biomedical Engineering at the University of Manitoba. To date, he has authored/co-authored over 485 peer-reviewed manuscripts, abstracts, and textbook chapters and has received numerous awards for his academic accomplishments. His research has been supported by over $17M in funding from provincial and federal sources (NSERC, CFI, CIHR, RM, NIH), including over $1M in trainee scholarships/fellowships to date. He has been awarded the Rudy Falk Clinician-Scientist Professorship (2019-2022), the Manitoba Public Insurance (MPI) Professorship in Neuroscience (2022-2023), and the Endowed MPI Chair in Neuroscience (2023-Present) at the University of Manitoba, while recently being recognized as a finalist for the 2025 NRC Steacie Prize in Natural Sciences and Engineering.
For further information:
https://umanitoba.ca/medicine/faculty-staff/frederick-zeiler
https://orcid.org/0000-0003-1737-0510
Scholarly contributions can bee seen via PubMed: